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Varenicline Stop Smoking Pill
A Pfizer drug shown to help more than one in five smokers stop smoking received federal approval on Thursday, adding another option to the limited pool of effective stop-smoking prescription medicines.
"It's not going to be a revolution, it's going to be a substantial step forward," Thomas Glynn, director of cancer science and trends at the American Cancer Society, said of varenicline. Glynn added that the greatest value will be for smokers who have tried Zyban or nicotine-replacement therapy but failed to quit.
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The drug also slows the release of dopamine, which cuts the craving to smoke that occurs when nicotine's effect wears off, said Pfizer research chemist Jotham Coe, who invented the drug. The best way of gaining knowledge about cigarette smoking quitting is by reading as much about it as possible. This can be best done through the Internet.
And at least two vaccines are being developed that could block nicotine from ever reaching the brain. The FDA does not recommend that Chantix be used with other smoking-cessation products. Its most common side effect is nausea.
"Tobacco use, particularly cigarette smoking, is the single most preventable cause of death in the United States and is responsible for a growing list of cancers, as well as chronic diseases including those of the lung and heart," said Dr. Scott Gottlieb, the FDA's Deputy Commissioner for Medical and Scientific Affairs. Never be reluctant to admit that you don't know. There is no one who knows everything. So if you don't know much about cigarette smoking quitting, all that has to be done is to read up on it!
One in five American adults, or nearly 45 million people, smoke. An estimated 32 million of those smokers would like to quit, according to the Centers for Disease Control and Prevention. Smoking kills nearly 440,000 Americans a year.
"It's a shield and at the same time, it stabilizes you and prevents you from having the lows, which lead to craving and withdrawal, but at the same time, it shields you from the highs," said Coe, a former 2 1/2 pack-a-day smoker who quit smoking a first time cold turkey and then a second time with the help of nicotine gum.
"My bet is that it will work as well as they do and, from the look of things, a little bit better," he said. Varenicline latches on to the same receptors in the brain that nicotine binds to when inhaled in cigarette smoke, an action that leads to the release of dopamine in the pleasure centers of the brain. Taking the drug blocks any inhaled nicotine from reinforcing that effect.
Both the FDA and European regulators recently shot down attempts by Sanofi-Aventis to gain approval for rimonabant, or Accomplia, as a stop-smoking aid. Both have recommended that the drug, which blocks the same pleasure centers in the body activated when pot smokers get the munchies, be approved for weight loss.
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Varenicline is only the second nicotine-free smoking cessation drug to gain FDA approval. Pfizer Inc. plans to market the twice-daily tablet as Chantix stop smoking pill. Variety is the spice of life. So we have added as much variety as possible to this matter on cigarette smoking quitting to make it's reading relevant, and interesting!
Quitting, as any smoker will tell you, isn't easy. Fewer than one in 20 smokers can do so without help, Schroeder said. With help, whether it's a drug, counseling or both, the success rate rises at most to roughly one in five, he added. Every cloud has a silver lining; so consider that this article on cigarette smoking quitting to be the silver lining to the clouds of articles on cigarette smoking quitting. It is this article that will add more spice to the meaning of cigarette smoking quitting.
Varenicline works in two ways, by cutting the pleasure of smoking and reducing the withdrawal symptoms that lead smokers to light up cigaret again. Most other stop-smoking pills are various nicotine-replacement therapies, sold by prescription and over the counter in gum, patch, lozenge, nasal spray or inhaler form. In 1997, the FDA approved bupropion, an antidepressant already sold as Wellbutrin but rebranded it as Zyban, an anti-smoking drug. Did you ever believe that there was so much to learn about cigarette smoking quitting? Neither did we! Once we got to write this article, it seemed to be endless.
Other clinical trials show the drug's effect is more pronounced in the short-term: 44 percent of patients quit smoking following a 12-week course of treatment with Chantix, compared to the 30 percent of Zyban patients who quit, according to Pfizer. However, smoking cessation experts said the longer-term data are more applicable, given the difficulty of quitting the habit for good. People always think that they know everything about everything; however, it should be known that no one is perfect in everything. There is never a limit to learning; even learning about cigarette smoking quitting.
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just another internet geeks
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